At least two Palestinians have been killed in the West Bank during protests against Israel's military campaign in Gaza, officials say.
At least 10,000 protesters marched from Ramallah towards East Jerusalem, where they were met by Israeli forces.
Around 200 protesters were wounded.
Meanwhile, the death toll in Gaza's fighting has continued to rise, with over 800 Palestinians and 33 Israelis killed since 8 July.
The Israeli military confirmed that troops had used "riot dispersal means" after West Bank protesters threw rocks and blocked a road with burning tyres.
Israel launched its military offensive against Gaza on 8 July with the declared objective of stopping Hamas firing rockets into Israel.
Israeli PM Benjamin Netanyahu said on Thursday he regretted each Palestinian civilian death, but said they were "the responsibility of Hamas".
Palestinian leaders in the West Bank have called for a day of anger on Friday, one of the last days of Ramadan.
Protests were also reported in Jerusalem on Thursday evening, after Israeli police prevented males under the age of 50 from visiting the al-Aqsa mosque.
At least 20 protesters were arrested after they threw rocks at police, Israeli police said.
Israeli media has described the West Bank protest as the largest since the 2000-2005 Palestinian protest movement, also known as the Second Intifada.
At least 13 people were killed and more than 200 injured when a UN-run school used as a shelter came under fire in Gaza on Thursday.
Palestinian families were in the school in Beit Hanoun, fleeing Israel's offensive against Hamas militants.
It is the fourth time in as many days that a UN facility has been hit.
Correspondents say pools of blood lay on the ground in the courtyard of the school in Beit Hanoun, and there was a large scorch mark where it appeared a shell had hit.
UN officials said that during the course of the day they had been trying to negotiate a window of time with the Israeli army for civilians to leave the area because of the heavy fighting.
Chris Gunness, a spokesman for the UN Relief and Works Agency for Palestine refugees (Unrwa), also said the Israeli army had been formally given the co-ordinates of the shelter in Beit Hanoun.
The Israel Defense Forces (IDF) said in a statement that it was in the midst of combat "with Hamas terrorists in the area of Beit Hanoun, who are using civilian infrastructure and international symbols as human shields".
"In the course of the afternoon, several rockets launched by Hamas from within the Gaza Strip landed in the Beit Hanoun area. The IDF is reviewing the incident," it said.
(BBC)